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Molecular mechanisms of osteoporosis
and age-related bone diseases

"Molecular mechanisms of osteoporosis and age-related bone diseases” is a highly multidisciplinary project led by IIT, bringing together three academic partners and one collaborator from three different countries, to unravel the molecular mechanisms involved in the degradation of osteoporotic bone, affecting bone tissue from the nanoscale up.
The project leverages a wide spectrum of expertise from different partners, such as:
  • computational modeling
  • nanomechanics and biophysics
  • biochemistry
  • in vivo biological experiments

The project adopts an innovative methodological approach, involving the synergistic use of data from both in-silico testing and wet laboratory experiments, with the aim of providing fundamental insights into the mechanics of osteoporosis. In addition, a branch of the project aims to explore the role of physical activity on the improvement of osteoporotic bone tissue, trying to clarify the biological, chemical and physical mechanisms through which this occurs.

Understanding the molecular mechanisms underlying osteoporosis can advance the knowledge of this disease, with a profound impact on society. At the same time, being able to elucidate the processes through which the benefits of physical activity on bone tissue manifest themselves, may open new paths for targeted interventions and bottom-up therapies for osteoporosis.

Partners